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What it is
MT-1 (afamelanotide) is a stabilized α-MSH analog engineered for enhanced MC1R agonism and improved proteolytic stability versus native α-MSH.
Research context
In vitro, it serves as a robust probe of melanocortin receptor pharmacology, particularly MC1R signaling via cAMP/PKA and downstream pigmentation-related gene programs. It’s used to examine receptor selectivity, internalization, and biased signaling relative to other melanocortin ligands.
Research relevance
  • Benchmark MC1R activation potency/efficacy and compare across melanocortin subtypes.
  • Study cAMP-driven transcription (e.g., MITF pathway) and receptor trafficking.
  • Evaluate structure–stability relationships among melanocortin analogs.
Common lab uses (examples)
  • cAMP accumulation assays in MC1R-expressing cell lines.
  • Westerns/qPCR for pigmentation-pathway markers in melanocyte models.
  • Radioligand competition or SPR for affinity/kinetics profiling.
Compliance
For laboratory research use only. Not for human or animal consumption.
 
 
 
Specs
  • Purity: ≥98% (HPLC)
  • Form: Lyophilized powder (vials)
  • Solubility: Sterile Water / Bacteriostatic Water / DMSO (depending on protocol)
  • Molecular Weight (approx.): ~190 Da
  • Appearance: White to off-white crystalline/lyophilized powder
Lab Notes
  • Storage (dry): −20 °C long-term, protected from light and humidity
  • After reconstitution: 2–8 °C (refrigerated); use within standard lab stability window
  • Handling: Maintain aseptic conditions; aliquot to minimize freeze–thaw cycles
  • Reconstitution: Dissolve in bacteriostatic water or sterile solution under sterile technique
Compliance
🔬 For laboratory research only. Not for human consumption, clinical use, or veterinary use.

Melanotan 1

SKU: #006
$40.00Price

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