What it is
KPV (Lys-Pro-Val) is the C-terminal tripeptide fragment of α-MSH (alpha-melanocyte-stimulating hormone). Despite its minimal length, it retains notable activity at melanocortin-related pathways, most prominently MC1R in cell systems.
Research context
KPV is used to probe melanocortin signaling and epithelial barrier biology in vitro. It’s studied for its effects on transcriptional regulators and cytokine profiles in epithelial and immune-lineage cells, often under inflammatory stimuli.
Research relevance
Mapping MC1R-dependent vs MC1R-independent anti-inflammatory signaling routes.
Examining barrier function readouts (TEER measurements) and tight-junction protein expression.
Minimal-motif SAR studies relative to longer α-MSH analogs.
Common lab uses (examples)
NF-κB reporter assays after pro-inflammatory challenge.
TEER assays in epithelial monolayers; immunostaining for claudins/occludin.
Receptor competition/binding in MC1R-expressing cell lines.
Compliance
For laboratory research use only. Not for human or animal consumption.
 
 
 
Specs
Purity: ≥98% (HPLC)
Form: Lyophilized powder (vials)
Solubility: Sterile Water / Bacteriostatic Water / DMSO (depending on protocol)
Molecular Weight (approx.): ~190 Da
Appearance: White to off-white crystalline/lyophilized powder
Lab Notes
Storage (dry): −20 °C long-term, protected from light and humidity
After reconstitution: 2–8 °C (refrigerated); use within standard lab stability window
Handling: Maintain aseptic conditions; aliquot to minimize freeze–thaw cycles
Reconstitution: Dissolve in bacteriostatic water or sterile solution under sterile technique
Compliance
🔬 For laboratory research only. Not for human consumption, clinical use, or veterinary use.