What it is
GHRP-2 (Growth Hormone–Releasing Peptide-2) is a GHSR-1a agonist in the growth hormone secretagogue class. It’s frequently used as a comparator to evaluate selectivity and potency versus other secretagogues.
Research context
GHRP-2 activates ghrelin receptor signaling, engaging Gq/PLC pathways, Ca²⁺ mobilization, and downstream transcriptional responses in pituitary-lineage and engineered cell systems. It’s valuable for studying receptor reserve, desensitization, and ligand-specific bias.
Research relevance
Dissecting GHSR-1a pharmacology and ligand structure–activity relationships.
Comparing signaling fingerprints (e.g., Ca²⁺ flux vs β-arrestin) across secretagogues.
Evaluating receptor internalization, recycling, and trafficking kinetics.
Common lab uses (examples)
Calcium imaging/FLIPR assays and IP₁ accumulation.
β-arrestin recruitment BRET assays and internalization imaging.
Cross-titration studies with antagonists/inverse agonists.
Compliance
For laboratory research use only. Not for human or animal consumption.
 
 
 
Specs
Purity: ≥98% (HPLC)
Form: Lyophilized powder (vials)
Solubility: Sterile Water / Bacteriostatic Water / DMSO (depending on protocol)
Molecular Weight (approx.): ~190 Da
Appearance: White to off-white crystalline/lyophilized powder
Lab Notes
Storage (dry): −20 °C long-term, protected from light and humidity
After reconstitution: 2–8 °C (refrigerated); use within standard lab stability window
Handling: Maintain aseptic conditions; aliquot to minimize freeze–thaw cycles
Reconstitution: Dissolve in bacteriostatic water or sterile solution under sterile technique
Compliance
🔬 For laboratory research only. Not for human consumption, clinical use, or veterinary use.