Overview:
5-Amino-1MQ is a small-molecule compound studied for its selective interaction with nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy balance, NAD⁺ utilization, and metabolic signaling. In research settings, 5-Amino-1MQ is used to explore how NNMT inhibition affects NAD⁺ preservation, AMPK activity, and metabolic pathway efficiency under controlled in-vitro conditions.
Scientific Background:
NNMT plays a key regulatory role in methylation cycles and NAD⁺ precursor turnover. In laboratory models, 5-Amino-1MQ suppresses NNMT activity, making it a useful reference point for studying NAD⁺ conservation, mitochondrial efficiency, and AMPK-linked signaling pathways. Researchers commonly evaluate its impact on cellular energetics, lipid-handling processes, and metabolic stress responses.
Why Researchers Study 5-Amino-1MQ:
By offering a non-stimulant pathway to explore metabolic enhancement, 5-Amino-1MQ allows researchers to study cellular energy optimization without relying on adrenergic mechanisms. Its unique interaction with NNMT makes it a valuable compound for investigating NAD⁺–dependent processes, metabolic regulation, and longevity-related pathways.
For Laboratory Research Use Only. Not for Human Consumption.
Specs
Purity: ≥98% (HPLC)
Form: Lyophilized powder (vials)
Solubility: Sterile Water / Bacteriostatic Water / DMSO (depending on protocol)
Molecular Weight (approx.): ~190 Da
Appearance: White to off-white crystalline/lyophilized powder
Lab Notes
Storage (dry): −20 °C long-term, protected from light and humidity
After reconstitution: 2–8 °C (refrigerated); use within standard lab stability window
Handling: Maintain aseptic conditions; aliquot to minimize freeze–thaw cycles
Reconstitution: Dissolve in bacteriostatic water or sterile solution under sterile technique
Compliance
🔬 For laboratory research only. Not for human consumption, clinical use, or veterinary use.
